NUVIGIL, Wakefulness, and Treated Obstructive Sleep Apnea
If you are currently being treated for obstructive sleep apnea
(OSA) but are still experiencing excessive sleepiness
(ES), NUVIGIL may be able to help improve your wakefulness.1
NUVIGIL can help improve wakefulness in patients with excessive sleepiness despite
treatment for obstructive sleep apnea (OSA)
Are you still feeling sleepy, even with treatment for OSA?
Ask your doctor about NUVIGIL for improved wakefulness throughout the day. NUVIGIL
is a prescription medicine used to improve wakefulness in adults who experience
excessive sleepiness despite treatment for obstructive sleep apnea.1
In clinical trials, patients who took NUVIGIL experienced significant improvement
in wakefulness throughout the day compared to patients taking a sugar pill (placebo).1
- In 2 studies of patients with ES due to treated OSA, NUVIGIL was assessed using
the Maintenance of Wakefulness Test (MWT), 6 times
throughout the day2
- The MWT is a measure of a person's degree of sleepiness2
- In these studies, the measures were averaged between 9 AM and 3
For patients who are being treated for their underlying airway obstruction but are
still sleepy, NUVIGIL improves wakefulness throughout the day1
In patients with OSA, NUVIGIL is used along with other medical treatments for this
sleep disorder. NUVIGIL is not a replacement for your current OSA treatment, and
it is important that you continue to use this treatment as prescribed by your doctor.
NUVIGIL may help with sleepiness caused by these conditions, but it may not stop
all of your sleepiness and does not take the place of sleep. Only you and your doctor
can decide if NUVIGIL is right for you, so make an appointment to see your doctor
While NUVIGIL is used to improve wakefulness in patients with treated OSA, it is
not used to treat the sleep disorders themselves or their other symptoms or consequences.1
NUVIGIL typically does not affect patients' ability to sleep when they need to sleep1
Based on sleep studies that measure nighttime breathing and brain and muscle activity,
NUVIGIL does NOT typically interfere with sleep.
5% of patients taking NUVIGIL reported trouble sleeping vs 1% of patients taking
a sugar pill (placebo).
NUVIGIL has an established safety profile1
- In clinical studies, most reported side effects were mild to moderate
- Common side effects of NUVIGIL were headache, nausea, dizziness, and trouble sleeping
- 7% of patients taking NUVIGIL stopped treatment due to side effects compared with
4% of patients taking a sugar pill (placebo)
NUVIGIL may cause serious side effects including a serious rash or a serious allergic
reaction that may affect parts of your body such as your liver or blood cells, and
may result in hospitalization and be life-threatening. If you develop a skin rash,
hives, sores in your mouth, blisters, swelling, peeling, or yellowing of the skin
or eyes, trouble swallowing or breathing, dark urine, or fever, stop taking NUVIGIL
and call your doctor right away or get emergency help.
NUVIGIL is not approved for children for any condition. It is not known if
NUVIGIL is safe or if it works in children under the age of 17.
NUVIGIL is a federally controlled substance [C-IV] because it has the potential
to be abused or lead to dependence. Please use NUVIGIL only as directed and keep
in a safe place to prevent misuse and abuse.